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Medical laboratory centre of expertise on Congenital Disorders of Glycosylation and Glycosylated ferritin
Apolipoprotein C-III
Apolipoprotein C-III (apoC-III) is a mucin core1 and mucin core2 O-glycosylated protein secreted by the liver and intestine.
In our experience, 2-DE of apoC-III showed mucin core1 abnormalities in ATP6V0A2-CDG, CCDC115-CDG, COG-CDG and in SLC35A1-CDG. For informations about glycosylation of apoC-III, you can contact us here.
We previously showed that MALDI-TOF of circulating apoC-III is an interesting technique for the fast screening of COG-CDG and ATP6V0A2-CDG.
Typical 2D patterns of apoC-III (click on the CDG)
- normal patterns
- COG-CDG
- ATP6V0A2-CDG
- CCDC115-CDG
- TMEM165-CDG
- SLC37A4-CDG
- hypersialylation
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